Me Using Luminesce Cellular Rejuvenation Serum. Apply a small amount to your fingertips. Massage evenly in an upward circular motion to the face and an upward motion to the neck. Use in the morning and at night after cleansing and before using other facial products. For best results, follow with Luminesce daily moisturizing complex in the morning and Luminesce advanced night repair at night. CAUTION: Avoid exposing the product to sunlight and extreme temperatures. Store product in a dry, cool and dark location. Color and viscosity may vary due to high concentration of proteins and growth factors in the product. Stop use and consult with doctor if irritation develops.